Animal models of anxiety and anxiolytic drug action

Dallas Treit*, Elif Engin, Kris McEown

*この研究の対応する著者

研究成果: Chapter

40 被引用数 (Scopus)

抄録

Animal models of anxiety attempt to represent some aspect of the etiology, symptomatology, or treatment of human anxiety disorders, in order to facilitate their scientific study. Within this context, animal models of anxiolytic drug action can be viewed as treatment models relevant to the pharmacological control of human anxiety. A major purpose of these models is to identify novel anxiolytic compounds and to study the mechanisms whereby these compounds produce their anxiolytic effects. After a critical analysis of "face," "construct," and "predictive" validity, the biological context in which animal models of anxiety are to be evaluated is specified. We then review the models in terms of their general pharmacological profiles, with particular attention to their sensitivity to 5-HT1A agonists and antidepressant compounds. Although there are important exceptions, most of these models are sensitive to one or perhaps two classes of anxiolytic compounds, limiting their pharmacological generality somewhat, but allowing in depth analysis of individual mechanisms of anxiolytic drug action (e.g., GABAA agonism). We end with a discussion of possible sources of variability between models in response to 5-HT1A agonists and antidepressant drugs.

本文言語English
ホスト出版物のタイトルBehavioral Neurobiology of Anxiety and Its Treatment
出版社Springer Verlag
ページ121-160
ページ数40
ISBN(印刷版)9783642029110
DOI
出版ステータスPublished - 2010 1月 1
外部発表はい

出版物シリーズ

名前Current Topics in Behavioral Neurosciences
2
ISSN(印刷版)1866-3370
ISSN(電子版)1866-3389

ASJC Scopus subject areas

  • 行動神経科学

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