Anterograde and retrograde amnesia of place discrimination in retrosplenial cortex and hippocampal lesioned rats

Asahi Haijima, Yukio Ichitani*

*この研究の対応する著者

研究成果: Article査読

31 被引用数 (Scopus)

抄録

Retrograde and anterograde amnesic effects of excitotoxic lesions of the rat retrosplenial cortex (RS) and hippocampus (HPC) were investigated. To test retrograde amnesia, rats were trained with two-arm place discrimination in a radial maze 4 wk and 1 d before surgery with a different arm pair, respectively. In the retention test 1 wk after surgery, both lesion groups showed temporally ungraded retrograde amnesia. To test anterograde amnesia, animals were trained after surgery to discriminate three arm pairs successively within a day, and then after interposition of 1- to 4-wk intervals, one of these pairs, respectively, was tested for retention. RS-lesioned rats could acquire these pairs of place discriminations rapidly but showed a retention interval-dependent impairment in the retention test. Conversely, HPC-lesioned rats took more sessions to acquire these pairs than did the control group, and their retention was ∼70% of correct performance regardless of retention interval. Results suggest that RS and HPC have different roles in spatial memory and that RS is important for remote memory process.

本文言語English
ページ(範囲)477-482
ページ数6
ジャーナルLearning and Memory
15
7
DOI
出版ステータスPublished - 2008 7月
外部発表はい

ASJC Scopus subject areas

  • 神経心理学および生理心理学
  • 認知神経科学
  • 細胞および分子神経科学

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