Anti-diabetic effects of chondroitin sulfate on normal and type 2 diabetic mice

Mihoko Moto, Naoko Takamizawa, Tetsuhei Shibuya, Asae Nakamura, Kaname Katsuraya, Kazuyasu Iwasaki, Katsuyuki Tanaka, Akihiko Murota

研究成果: Article

2 引用 (Scopus)

抜粋

We evaluated the inhibitory effects of CS with different molecular weights from 170,000 to 10,000 Da on a-glucosidase activity in vitro. Low-molecular-weight CS (<16,000 Da) showed a higher inhibition of a-glucosidase activity than high-molecular-weight CS. In addition, we examined the effects of a single administration of low-molecular-weight CS on postprandial blood glucose in ICR mice. Low-molecular-weight CS inhibited the elevation of postprandial blood glucose in mice loaded with sucrose or starch as the source of carbohydrates. Finally, we investigated the anti-diabetic effects of daily administration of low- molecular-weight CS using type 2 diabetes model KK-Ay mice. The elevation of fasting blood glucose was inhibited in the CS group. These results suggest that the administration of low-molecular-weight CS prevents the elevation in the postprandial blood glucose level by reducing the digestion of carbohydrates in the gastrointestinal tract, leading to reductions of hyperglycemia in KK-Ay mice.

元の言語English
ページ(範囲)336-340
ページ数5
ジャーナルJournal of Functional Foods
40
DOI
出版物ステータスPublished - 2018 1 1

    フィンガープリント

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

これを引用

Moto, M., Takamizawa, N., Shibuya, T., Nakamura, A., Katsuraya, K., Iwasaki, K., Tanaka, K., & Murota, A. (2018). Anti-diabetic effects of chondroitin sulfate on normal and type 2 diabetic mice. Journal of Functional Foods, 40, 336-340. https://doi.org/10.1016/j.jff.2017.11.019