Anti-inflammatory effects of seeds of the tropical fruit camu-camu (Myrciaria dubia)

Kazunaga Yazawa, Katsumi Suga, Atsushi Honma, Miyuki Shirosaki, Tomoyuki Koyama*

*この研究の対応する著者

研究成果: Article査読

29 被引用数 (Scopus)

抄録

The methanolic extract of seeds of the tropical fruit camu-camu was screened for its anti-inflammatory activity in carrageenan-induced paw edema model mice. The extract significantly suppressed both the formation of edema in mice by oral administration and the release of nitric oxide from macrophage-derived RAW 264.7 cells in vitro. Based on the results of a spectroscopic analysis, the active compound was identified by in vivo bioassay-guided fractionation to be 3β -hydroxy-lup-20(29)-en-28-oic acid, betulinic acid, known as an anti-inflammatory triterpenoid. These findings suggest that camu-camu seed extract is a potentially useful material as a source of betulinic acid and as a functional food for prevention of immune-related diseases.

本文言語English
ページ(範囲)104-107
ページ数4
ジャーナルJournal of Nutritional Science and Vitaminology
57
1
DOI
出版ステータスPublished - 2011
外部発表はい

ASJC Scopus subject areas

  • 医学(その他)
  • 栄養および糖尿病

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