Anti-trypanosomal compound, sagamilactam, a new polyene macrocyclic lactam from Actinomadura sp. K13-0306

Toru Kimura, Masato Iwatsuki, Yukihiro Asami, Aki Ishiyama, Rei Hokari, Kazuhiko Otoguro, Atsuko Matsumoto, Noriko Sato, Kazuro Shiomi, Yoko Takahashi*, Satoshi Omura, Takuji Nakashima

*この研究の対応する著者

研究成果: Article査読

15 被引用数 (Scopus)

抄録

A new antibiotic, designated sagamilactam, was isolated from the cultured broth of Actinomadura sp. K13-0306 by Diaion HP-20, silica gel and octadecylsilane column chromatography followed by purification by HPLC. The chemical structure of the new compound was elucidated by spectroscopic analyses, including NMR and MS. The structure of sagamilactam proved to be a new compound consisting of a polyunsaturated and polyoxygenated 34-membered macrocyclic lactam containing diene, triene and tetraene conjugated olefins and a decalin moiety. Sagamilactam showed antitrypanosomal activity with an IC 50 value of 0.25±0.11 μM.

本文言語English
ページ(範囲)818-824
ページ数7
ジャーナルJournal of Antibiotics
69
11
DOI
出版ステータスPublished - 2016 11 1
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 創薬

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