We have successfully synthesized hollow biphasic calcium-phosphate microspheres consisting of the β-tricalcium phosphate (β-Ca 3(PO4)2; β-TCP) and calcium-deficient hydroxyapatite (DAp) using an ultrasonic spray-pyrolysis technique. The resulting hollow biphasic microspheres have been applied as a carrier of a drug delivery system (DDS) for medical treatment of cancers. An anti-angiogenic agent, TNP-470 (Takeda), was used as one of drug models. We have performed biological evaluations in vitro and in vivo using the biodegradable calcium-phosphate microsphere loaded with TNP-470. The results of in vitro and in vivo testing indicate that the microspheres loaded with TNP-470 inhibit i) the proliferation of FU-MMT-3 cells as a tumor model and ii) the enlargement of tumor sizes as a model of nude mice injected with FU-MMT-3 cells. The biological evaluations demonstrate that the present microspheres loaded with TNP-470 have an excellent anti-tumorigenesis effect.
|ジャーナル||Key Engineering Materials|
|出版ステータス||Published - 2008|
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