Anxiolytic activities of pentanthrene type heterocyclic compounds

T. Imamura, A. Noda, S. Shibata, S. Watanabe, H. Noda, Y. Ono, S. Goto, Y. Inoue

研究成果: Article査読

1 被引用数 (Scopus)

抄録

A series of pentanthrene type heterocyclic compounds were synthesized and evaluated for anxiolytic activities by three kinds of behavioral pharmacological tests. Several compounds showed anxiolytic activities. In particular, s-triazolo[3,4-a]phthalazine (Tri-P) and 3-propyl derivatives of Tri-P(PTP) showed remarkable activities, although the activities were slightly lower than those of diazepam. The results suggested that Tri-P or PTP is a useful lead compound for the development of the antianxietic agents. The relationship between the structure and anxiolytic activity, and the inducing mechanism of the activity was discussed.

本文言語English
ページ(範囲)400-405
ページ数6
ジャーナルYakugaku Zasshi
113
5
DOI
出版ステータスPublished - 1993
外部発表はい

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

フィンガープリント 「Anxiolytic activities of pentanthrene type heterocyclic compounds」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル