TY - JOUR
T1 - Application of a statistical mechanical model for protein folding to a three-dimensional lattice protein
AU - Abe, Haruo
AU - Wako, Hiroshi
PY - 2004/5/1
Y1 - 2004/5/1
N2 - A statistical mechanical model for protein folding is applied to the three-dimensional lattice protein using a foldable amino acid sequence. The key to the model lies in the concept of its local structure, defined as a continuous region which takes the same local conformation as in the native conformation, and in the assumption of the absence of interactions between local structures. The partition function is precisely calculated for a given native conformation without any adjustable parameters. The model can well reproduce the equilibrium thermodynamic quantities obtained from the simulation.
AB - A statistical mechanical model for protein folding is applied to the three-dimensional lattice protein using a foldable amino acid sequence. The key to the model lies in the concept of its local structure, defined as a continuous region which takes the same local conformation as in the native conformation, and in the assumption of the absence of interactions between local structures. The partition function is precisely calculated for a given native conformation without any adjustable parameters. The model can well reproduce the equilibrium thermodynamic quantities obtained from the simulation.
KW - 3d lattice protein
KW - Monte Carlo simulation
KW - Protein folding
KW - Structural transition
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U2 - 10.1143/JPSJ.73.1143
DO - 10.1143/JPSJ.73.1143
M3 - Article
AN - SCOPUS:20544466364
VL - 73
SP - 1143
EP - 1146
JO - Journal of the Physical Society of Japan
JF - Journal of the Physical Society of Japan
SN - 0031-9015
IS - 5
ER -