Application of dimethylsulphoxide(DMSO) / trifluoroacetic acid(TFA) oxidation to the synthesis of cystine-containing peptide

Akira Otaka, Takaki Koide, Atsuko Shide, Nobutaka Fujii

研究成果: Article査読

76 被引用数 (Scopus)

抄録

S-protected cysteine derivatives [Cys(Trt), Cys(MBzl), Cys(Dbs), Cys(Bzh)] as well as cysteine were converted to cystine by the action of DMSO / TFA; as examples, two model peptides, oxytocin and an α-human calcitonin gene-related peptide (α-hCGRP), were prepared by this reaction.

本文言語English
ページ(範囲)1223-1226
ページ数4
ジャーナルTetrahedron Letters
32
9
DOI
出版ステータスPublished - 1991 2 25
外部発表はい

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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