Application of hydroxyapatite-sol as drug carrier

Seisuke Kano, Atsushi Yamazaki, Ryohei Otsuka, Masataka Ohgaki, Masaru Akao, Hideki Aoki

研究成果: Article査読

43 被引用数 (Scopus)

抄録

The application of hydroxyapatite-sol as a drug carrier is being developed. Hydroxyapatite-sol which is a suspension consisting of hydroxyapatite nano-crystals, was synthesized using an ultrasonic homogenizer. The size of the crystals was 40 × 15 × 10 nm3 on average and their specific surface area was 100 m2/g. An amount of a glycoside antibiotics adsorbed onto hydroxyapatite nano-crystals was measured. The drug adsorbed 0.2 mg per 1 mg of hydroxyapatite. The affect of the drug adsorbed onto the hydroxyapatite was investigated using cancer cells. The drug, adsorbed onto the hydroxyapatite nano-crystals, inhibited cancer cell growth.

本文言語English
ページ(範囲)283-290
ページ数8
ジャーナルBio-Medical Materials and Engineering
4
4
DOI
出版ステータスPublished - 1994

ASJC Scopus subject areas

  • 生体材料
  • 生体医工学

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