Application of infrared attenuated total reflection spectroscopy to in situ analysis of atheromatous plaques in aorta

Atsushi Nakamura, Takehiro Koga, Makoto Fujimaki, Yoshimichi Ohki, Takayuki Sota, Kristina Lipinska-Kalita, Tsuneyuki Nagae, Shin Ishimaru, Katsuo Aizawa

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Ex vivo infrared attenuated total reflection (ATR) spectroscopic studies have been carried out to observe the accumulation of cholesterol ester in atheromatous plaques. It has been found that ATR spectra can be successfully obtained from the intima side of aorta and give the same information as the transmission spectra. This means, the ATR spectra include information about the chemical composition of atheromatous plaques together with the degree of eventual lesions. We have demonstrated that ATR microspectroscopic measurements can give images of atheromatous plaques distribution and enable in situ observation of the relative amount of accumulated cholesterol ester. The results clearly indicate that the ATR spectroscopy enables spectroscopic diagnoses in vivo as well as in vitro.

本文言語English
ページ(範囲)L490-L492
ジャーナルJapanese Journal of Applied Physics, Part 2: Letters
39
6 A
出版ステータスPublished - 2000 12 3

ASJC Scopus subject areas

  • 工学(全般)
  • 物理学および天文学(その他)
  • 物理学および天文学(全般)

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