Application of poly-l-lactic acid nanosheet as a material for wound dressing

Shimpo Aoki, Manabu Kinoshita, Hiromi Miyazaki, Akihiro Saito, Toshinori Fujie, Keiichi Iwaya, Shinji Takeoka, Daizoh Saitoh

研究成果: Article査読

13 被引用数 (Scopus)

抄録

The authors evaluated the efficacy of an ultrathin nanosheet consisting of poly-L-lactic acid (75 nm thick) as a wound dressing material. A full-thickness skin defect was made on the backs of mice and overlapped with or without the poly-L-lactic acid nanosheet. Wound healing was more rapidly improved by overlapping with the nanosheet, especially in the early healing period (at 4 to 6 days). The remaining wound area in the treatment group was significantly smaller at 4 days than in the control group. Histologically, a clear layer was observed over the granulation layer by the nanosheet therapy at 4 days. Thus, overlapping therapy with the poly-L-lactic acid nanosheet accelerated wound healing and formed a clear layer just above the granulation tissue. The poly-L-lactic acid nanosheet may have potential as a novel wound dressing to promote wound healing.

本文言語English
ページ(範囲)236-240
ページ数5
ジャーナルPlastic and Reconstructive Surgery
131
2
DOI
出版ステータスPublished - 2013 2

ASJC Scopus subject areas

  • Surgery

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