Aqueous elution control in wettability modulated microchannels grafted with thermoresponsive polymers

Naokazu Idota, Akihiko Kikuchi, Jun Kobayashi, Kiyotaka Sakai, Teruo Okano

研究成果: Conference contribution

抄録

Temperature-dependent aqueous wettability of poly(N-isopropylacrylamide) (PIPAAm)-grafted surfaces was regulated by grafted polymer layer thickness and basic hydrophobicities of the polymer-grafted surfaces. Thermoresponsive surfaces with controlled polymer layer thickness were prepared by surface-initiated atom transfer radical polymerization (ATRP). Static contact angles for both surfaces were drastically changed in response to temperature alteration. Hydrophilic property of PIPAAm-grafted surfaces depends on polymer layer thickness at low temperature range. More hydrophobic surface properties were observed for poly (n-butyl methacrylate) (PBMA)-b-PIPAAm-grafted surfaces than IPAAm homopolymer-grafted surfaces above PIPAAm's transition. The changes of static contact angles for both surfaces were drastically changed in response to temperature alteration temperature. Well-defined thermoresponsive microchannels were then fabricated for elution control of steroids through the modulation of surface characteristics by temperature. Using PIPAAm-grafted hollow capillaries, baseline separation of steroids was successfully achieved within 10min by changing only temperature. Furthermore, the hydrophobic testosterone showed stronger hydrophobic interaction on more hydrophobized PBMA-b-PIPAAm-grafted surfaces above the PIPAAm's transition temperature.

本文言語English
ホスト出版物のタイトルMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
出版社Transducer Research Foundation
ページ1264-1266
ページ数3
1
ISBN(印刷版)0974361119, 9780974361116
出版ステータスPublished - 2005
イベント9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA
継続期間: 2005 10 92005 10 13

Other

Other9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
CityBoston, MA
Period05/10/905/10/13

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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