Assessment of the role of adrenoceptor function in ischemia-induced impairment of 2-deoxyglucose uptake and CA1 field potential in rat hippocampal slices

Shibata Shigenobu, Kodama Koutaroh, Tominaga Keiko, Ueki Showa, Watanabe Shigenori

研究成果: Article査読

11 被引用数 (Scopus)

抄録

The release of catecholamines, dopamine and noradrenaline has been suggested to play a role in mediating ischemic damage in susceptible brain regions, the hippocampus and striatum. We now provide evidence that suggests a role for adrenoceptors in the deficit of 2-dcoxyglucosc uptake and CA1 field potential induced in hippocampal slices by hypoxia/hypoglycemia (ischemia). Treatment with α1- or β-adrenoceptor agonists or cAMP potentiated an ischemia-induced decline of both 2-deoxyglucose uptake and CA1 field potential in hippocampal slices, whereas α1- or β-adrenoceptor antagonists, or α2-adrenoceptor agonists produce a remarkable neuroprotective action against these deficits. The results indicate that stimulation of adrenoceptors may play a detrimental role in the development of ischemic damage, and suggest a neuroprotectivc action for adrenoceptor antagonists, which may lessen the functional deficits induced by ischemia.

本文言語English
ページ(範囲)255-260
ページ数6
ジャーナルEuropean Journal of Pharmacology
221
2-3
DOI
出版ステータスPublished - 1992 10 20
外部発表はい

ASJC Scopus subject areas

  • Pharmacology

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