Association between dietary intake and the prevalence of tumourigenic bacteria in the gut microbiota of middle-aged Japanese adults

Daiki Watanabe, Haruka Murakami, Harumi Ohno, Kumpei Tanisawa, Kana Konishi, Yuta Tsunematsu, Michio Sato, Noriyuki Miyoshi, Keiji Wakabayashi, Kenji Watanabe, Motohiko Miyachi

研究成果: Article査読

抄録

The relative contribution of diet to colorectal cancer (CRC) incidence is higher than that for other cancers. Animal models have revealed that Escherichia coli containing polyketide synthase (pks+E. coli) in the gut participates in CRC development. The purpose of this cross-sectional study was to examine the relationship between dietary intake and the prevalence of pks+E. coli isolated from the microbiota in faecal samples of 223 healthy Japanese individuals. Dietary intake was assessed using a previously validated brief-type self-administered diet history questionnaire. The prevalence of pks+E. coli was evaluated using faecal samples collected from participants and specific primers that detected pks+E. coli. The prevalence of pks+E. coli was 26.9%. After adjusting for baseline confounders, the prevalence of pks+E. coli was negatively associated with the intake of green tea (odds ratio [OR], 0.59 [95% confidence interval (CI) 0.30–0.88] per 100 g/1,000 kcal increment) and manganese (OR, 0.43 [95% CI 0.22–0.85] per 1 mg/1,000 kcal increment) and was positively associated with male sex (OR, 2.27 [95% CI 1.05–4.91]). While futher studies are needed to validate these findings, these results provide insight into potential dietary interventions for the prevention of CRC.

本文言語English
論文番号15221
ジャーナルScientific reports
10
1
DOI
出版ステータスPublished - 2020 12 1
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ASJC Scopus subject areas

  • General

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