Association of plasma pentraxin 3 with arterial stiffness in overweight and obese individuals

Asako Miyaki, Seiji Maeda*, Youngju Choi, Nobuhiko Akazawa, Miki Eto, Kiyoji Tanaka, Ryuichi Ajisaka

*この研究の対応する著者

研究成果: Article査読

29 被引用数 (Scopus)

抄録

BACKGROUNDObesity and increased arterial stiffness are independent risk factors for cardiovascular disease. The degree of arterial stiffness in obese individuals is greater than that in normal-weight subjects. Pentraxin 3 (PTX3) is mainly produced by vascular tissues and exerts a cardioprotective effect. However, the relationship between PTX3 and arterial stiffness in obese individuals has not yet been clarified. In this study, we examined the relationships between obesity, arterial stiffness, and PTX3 levels in 282 subjects.METHODSAll participants were classified as normal weight, overweight, or obese on the basis of their body mass index. We measured the brachial-ankle pulse wave velocity (baPWV; an index of arterial stiffness) and plasma PTX3 concentrations in all subjects. Additionally, the carotid-femoral PWV (cfPWV) was measured in 173 subjects.RESULTSWe found that baPWV and cfPWV in overweight and obese subjects were significantly higher than those in normal-weight subjects. Plasma PTX3 concentrations in normal-weight subjects were significantly higher than those in overweight and obese subjects. Moreover, PTX3 had a significant negative correlation with baPWV. However, stepwise multivariable linear regression analysis did not indicate any associations between these parameters.CONCLUSIONSArterial stiffness is increased in overweight and obese individuals. The increase in arterial stiffness may, at least in part, be associated with an obesity-related reduction in plasma PTX3 concentrations.

本文言語English
ページ(範囲)1250-1255
ページ数6
ジャーナルAmerican Journal of Hypertension
26
10
DOI
出版ステータスPublished - 2013 10
外部発表はい

ASJC Scopus subject areas

  • 内科学

フィンガープリント

「Association of plasma pentraxin 3 with arterial stiffness in overweight and obese individuals」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル