Associations among objectively measured physical activity, fasting plasma homocysteine concentration, and MTHFR C677T genotype

Haruka Murakami*, Motoyuki Iemitsu, Kiyoshi Sanada, Yuko Gando, Yumi Ohmori, Ryoko Kawakami, Satoshi Sasaki, Izumi Tabata, Motohiko Miyachi

*この研究の対応する著者

研究成果: Article査読

17 被引用数 (Scopus)

抄録

Elevated fasting plasma homocysteine (Hcy) level is a vascular disease risk factor. Plasma Hcy is affected by 5,10-methylenetetrahydofolate reductase (MTHFR) genotype and dietary folate intake. This cross-sectional study in 434 Japanese adults examined the associations among objectively measured physical activity (PA), plasma Hcy adjusting for dietary folate intake, and MTHFR C677T genotype. Daily PA was measured by triaxial accelerometry and all subjects completed a questionnaire about their dietary habits. Plasma Hcy and MTHFR C677T genotype were determined. Plasma Hcy in subjects with the TT genotype was significantly higher than in those with CC or CT genotype (p<0.001). Plasma Hcy was significantly different between ≥200 (7.6 ± 0.2 nmol/mL) and<200 μg/ day (8.3 ± 0.3 nmol/mL) folate intake groups (p = 0.003). There were no differences in plasma Hcy adjusting for age, sex, and folate intake between groups according to PA category in all subjects. However, there were significant interactions between time spent in light PA (p = 0.003), vigorous PA (p = 0.001), or inactivity (p = 0.004), and MTHFR genotype. In only the TT genotype, shorter time spent in light PA was associated with higher plasma Hcy than a longer time spent in light PA (11.5 ± 3.3 nmol/mL vs. 8.5 ± 3.3 nmol/mL, p<0.001), and longer time spent in vigorous PA and inactivity were associated with higher plasma Hcy (11.8 ± 3.3 nmol/mL vs. 8.4 ± 3.2 nmol/mL, 11.6 ± 3.3 nmol/mL vs. 8.4 ± 3.3 nmol/mL, respectively, p<0.001). In conclusion, light and vigorous PA were associated with plasma Hcy only in the TT genotype, but there were no such associations in all genotypes.

本文言語English
ページ(範囲)2997-3005
ページ数9
ジャーナルEuropean Journal of Applied Physiology
111
12
DOI
出版ステータスPublished - 2011 12
外部発表はい

ASJC Scopus subject areas

  • 整形外科およびスポーツ医学
  • 公衆衛生学、環境および労働衛生
  • 生理学(医学)

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