Associations of endogenous sex hormones and sex hormone-binding globulin with lipid profiles in aged Japanese men and women

Toshiyuki Yasui, Hirokazu Uemura, Minoru Irahara, Makoto Arai, Noriko Kojimahara, Ryugo Okabe, Yasutomo Ishii, Shin ichi Tashiro, Hiroshi Sato

    研究成果: Article

    27 引用 (Scopus)

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    Background: The associations of endogenous estrogen with lipid profiles and insulin resistance were conflicting in both men and women. We determined the associations of serum estradiol level and free estradiol index (FEI) with lipid profiles and insulin resistance in aged Japanese men and women. Methods: One hundred seventy-four men and 208 postmenopausal women aged from 50 to 85 y were included in this study. Lipid profiles, fasting glucose and insulin as well as estradiol, testosterone, dehydroepiandrosterone-sulfate (DHEA-S) and sex hormone-binding globulin (SHBG) in serum were measured. Results: Serum estradiol concentration in men showed a significant and negative correlation with high density lipoprotein-cholesterol (HDL-C) concentration and a significant and positive correlation with triglyceride (TG) after adjustment for age and body mass index (BMI). In addition, estradiol level was positively correlated with insulin and HOMA index. In women, serum levels of estradiol and testosterone were not correlated with lipid profiles and insulin resistance. SHBG concentration was negatively correlated with TG after adjustment for age and BMI in women. Conclusion: Endogenous estradiol level is associated with unfavorable lipid profiles and insulin resistance in aged men. In aged women, SHBG level is associated with favorable lipid profiles.

    元の言語English
    ページ(範囲)43-47
    ページ数5
    ジャーナルClinica Chimica Acta
    398
    発行部数1-2
    DOI
    出版物ステータスPublished - 2008 12

      フィンガープリント

    ASJC Scopus subject areas

    • Biochemistry
    • Clinical Biochemistry
    • Biochemistry, medical

    これを引用

    Yasui, T., Uemura, H., Irahara, M., Arai, M., Kojimahara, N., Okabe, R., Ishii, Y., Tashiro, S. I., & Sato, H. (2008). Associations of endogenous sex hormones and sex hormone-binding globulin with lipid profiles in aged Japanese men and women. Clinica Chimica Acta, 398(1-2), 43-47. https://doi.org/10.1016/j.cca.2008.08.006