Asymmetric and highly stereoselective synthesis of the def-ring moiety of (-)-FR182877 and its derivative inducing mitotic arrest

Yu Kobayakawa, Yusuke Mori, Hideki Okajima, Yasuhiko Terada, Masahisa Nakada

    研究成果: Article

    6 引用 (Scopus)

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    The asymmetric and highly stereoselective synthesis of compound 1, which corresponds exactly to the DEF-ring moiety of (-)-FR182877, and the biological activities of its derivatives are described. All derivatives of 1 showed no activity in the tubulin polymerization assay, but one derivative was shown to have the ability to induce mitotic arrest by interfering with microtubule dynamics, and the cellular effects are similar to those of paclitaxel.

    元の言語English
    ページ(範囲)2086-2089
    ページ数4
    ジャーナルOrganic Letters
    14
    発行部数8
    DOI
    出版物ステータスPublished - 2012 4 20

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    ASJC Scopus subject areas

    • Organic Chemistry
    • Physical and Theoretical Chemistry
    • Biochemistry

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