Asymmetric autocatalysis of pyrimidyl alkanol induced by optically active 1,1′-binaphthyl, an atropisomeric hydrocarbon, generated from spontaneous resolution on crystallization

Itaru Sato, Shunji Osanai, Kousuke Kadowaki, Tadashi Sugiyama, Takanori Shibata, Kenso Soai

研究成果: Article査読

27 被引用数 (Scopus)

抄録

An atropisomeric hydrocarbon, (R)-1,1′-binaphthyl, acts as a chiral initiator of asymmetric autocatalysis of pyrimidyl alkanol in the enantioselective addition of diisopropylzinc to pyrimidine-5-carbaldehyde to afford (S)-5-pyrimidyl alkanol 2 with 96% ee. On the other hand, in the presence of (S)-1,1′-binaphthyl, the reaction affords (R)-2 with 94% ee.

本文言語English
ページ(範囲)168-169
ページ数2
ジャーナルChemistry Letters
2
DOI
出版ステータスPublished - 2002 2 5
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)

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