Asymmetric synthesis of pyrimidyl alkanol without adding chiral substances by the addition of diisopropylzinc to pyrimidine-5-carbaldehyde in conjunction with asymmetric autocatalysis

Kenso Soai; Itaru Sato; Takanori Shibata; Soichiro Komiya; Masanobu Hayashi; Yohei Matsueda; Hikaru Imamura; Tadakatsu Hayase; Hiroshi Morioka; Hayami Tabira; Jun Yamamoto; Yasunori Kowata

doi:10.1016/S0957-4166(02)00791-7

Asymmetric synthesis of pyrimidyl alkanol without adding chiral substances by the addition of diisopropylzinc to pyrimidine-5-carbaldehyde in conjunction with asymmetric autocatalysis

Kenso Soai^*, Itaru Sato, Takanori Shibata, Soichiro Komiya, Masanobu Hayashi, Yohei Matsueda, Hikaru Imamura, Tadakatsu Hayase, Hiroshi Morioka, Hayami Tabira, Jun Yamamoto, Yasunori Kowata

^*この研究の対応する著者

研究成果: Article › 査読

206 被引用数 (Scopus)

抄録

Enantiomerically enriched pyrimidyl alkanol with either S or R configuration was obtained stochastically from the reaction between pyrimidine-5-carbaldehyde and diisopropylzinc without adding chiral substances in conjunction with subsequent asymmetric autocatalysis, leading to amplification of the enantiomeric excess.

本文言語	English
ページ（範囲）	185-188
ページ数	4
ジャーナル	Tetrahedron Asymmetry
巻	14
号	2
DOI	https://doi.org/10.1016/S0957-4166(02)00791-7
出版ステータス	Published - 2003 1月 17
外部発表	はい

ASJC Scopus subject areas

触媒
物理化学および理論化学
有機化学
無機化学

文献へのアクセス

10.1016/S0957-4166(02)00791-7

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フィンガープリント

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引用スタイル

Soai, K., Sato, I., Shibata, T., Komiya, S., Hayashi, M., Matsueda, Y., Imamura, H., Hayase, T., Morioka, H., Tabira, H., Yamamoto, J., & Kowata, Y. (2003). Asymmetric synthesis of pyrimidyl alkanol without adding chiral substances by the addition of diisopropylzinc to pyrimidine-5-carbaldehyde in conjunction with asymmetric autocatalysis. Tetrahedron Asymmetry, 14(2), 185-188. https://doi.org/10.1016/S0957-4166(02)00791-7

Asymmetric synthesis of pyrimidyl alkanol without adding chiral substances by the addition of diisopropylzinc to pyrimidine-5-carbaldehyde in conjunction with asymmetric autocatalysis. / Soai, Kenso; Sato, Itaru; Shibata, Takanori; Komiya, Soichiro; Hayashi, Masanobu; Matsueda, Yohei; Imamura, Hikaru; Hayase, Tadakatsu; Morioka, Hiroshi; Tabira, Hayami; Yamamoto, Jun; Kowata, Yasunori.

In: Tetrahedron Asymmetry, Vol. 14, No. 2, 17.01.2003, p. 185-188.

研究成果: Article › 査読

Soai, K, Sato, I, Shibata, T, Komiya, S, Hayashi, M, Matsueda, Y, Imamura, H, Hayase, T, Morioka, H, Tabira, H, Yamamoto, J & Kowata, Y 2003, 'Asymmetric synthesis of pyrimidyl alkanol without adding chiral substances by the addition of diisopropylzinc to pyrimidine-5-carbaldehyde in conjunction with asymmetric autocatalysis', Tetrahedron Asymmetry, vol. 14, no. 2, pp. 185-188. https://doi.org/10.1016/S0957-4166(02)00791-7

Soai, Kenso ; Sato, Itaru ; Shibata, Takanori ; Komiya, Soichiro ; Hayashi, Masanobu ; Matsueda, Yohei ; Imamura, Hikaru ; Hayase, Tadakatsu ; Morioka, Hiroshi ; Tabira, Hayami ; Yamamoto, Jun ; Kowata, Yasunori. / Asymmetric synthesis of pyrimidyl alkanol without adding chiral substances by the addition of diisopropylzinc to pyrimidine-5-carbaldehyde in conjunction with asymmetric autocatalysis. In: Tetrahedron Asymmetry. 2003 ; Vol. 14, No. 2. pp. 185-188.

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