Asymmetric synthesis of pyrimidyl alkanol without adding chiral substances by the addition of diisopropylzinc to pyrimidine-5-carbaldehyde in conjunction with asymmetric autocatalysis

Kenso Soai, Itaru Sato, Takanori Shibata, Soichiro Komiya, Masanobu Hayashi, Yohei Matsueda, Hikaru Imamura, Tadakatsu Hayase, Hiroshi Morioka, Hayami Tabira, Jun Yamamoto, Yasunori Kowata

研究成果: Article

186 引用 (Scopus)

抜粋

Enantiomerically enriched pyrimidyl alkanol with either S or R configuration was obtained stochastically from the reaction between pyrimidine-5-carbaldehyde and diisopropylzinc without adding chiral substances in conjunction with subsequent asymmetric autocatalysis, leading to amplification of the enantiomeric excess.

元の言語English
ページ(範囲)185-188
ページ数4
ジャーナルTetrahedron Asymmetry
14
発行部数2
DOI
出版物ステータスPublished - 2003 1 17
外部発表Yes

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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