Asymmetric synthesis of various chiral 5-pyrimidyl-alkanols by the enantios elective alkylation of pyrimidine-5-carbaldehydes with dialkylzincs in the presence of chiral amino alcohols

Takanori Shibata, Tadakatsu Hayase, Yasuyuki Aiba, Hayami Tabira, Kenso Soai

研究成果: Article査読

7 被引用数 (Scopus)

抄録

(1S,2R)-N,N-Dibutylnorephedrine catalyzes the enantioselective addition of dialkylzincs to various pyrimidine-5-carbaldehydes. Ethylation and butylation proceed with high enantioselectivities (up to 94% e.e.) to give optically active secondary 5-pyrimidyl alkanols.

本文言語English
ページ(範囲)235-240
ページ数6
ジャーナルHeterocycles
46
1
DOI
出版ステータスPublished - 1997 1 1
外部発表はい

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

フィンガープリント 「Asymmetric synthesis of various chiral 5-pyrimidyl-alkanols by the enantios elective alkylation of pyrimidine-5-carbaldehydes with dialkylzincs in the presence of chiral amino alcohols」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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