Attenuation of the contingency detection effect in the extrastriate body area in autism spectrum disorder

Yuko Okamoto, Ryo Kitada, Hiroki C. Tanabe, Masamichi J. Hayashi, Takanori Kochiyama, Toshio Munesue, Makoto Ishitobi, Daisuke N. Saito, Hisakazu T. Yanaka, Masao Omori, Yuji Wada, Hidehiko Okazawa, Akihiro T. Sasaki, Tomoyo Morita, Shoji Itakura, Hirotaka Kosaka, Norihiro Sadato*

*この研究の対応する著者

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Detection of the contingency between one's own behavior and consequent social events is important for normal social development, and impaired contingency detection may be a cause of autism spectrum disorder (ASD). To depict the neural underpinnings of this contingency effect, 19 adults with ASD and 22 control participants underwent functional MRI while imitating another's actions and their actions being imitated by the other. As the extrastriate body area (EBA) receives efference copies of one's own movements, we predicted that the EBA would show an atypical response during contingency detection in ASD. We manipulated two factors: the congruency of the executed and observed actions, and the order of action execution and observation. Both groups showed the congruency effect in the bilateral EBA during imitation. When action preceded observation, the left EBA of the control group showed the congruency effect, representing the response to being imitated, indicating contingency detection. The ASD group showed a reduced contingency effect in the left EBA. These results indicate that the function of the EBA in the contingency detection is altered in ASD.

本文言語English
ページ(範囲)66-76
ページ数11
ジャーナルNeuroscience Research
87
C
DOI
出版ステータスPublished - 2014
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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