Axinelloside A, an unprecedented highly sulfated lipopolysaccharide inhibiting telomerase, from the marine sponge, Axinella infundibula

Kaoru Warabi, Toshiyuki Hamada, Yoichi Nakao, Shigeki Matsunaga, Hiroshi Hirota, Rob W.M. Van Soest, Nobuhiro Fusetani

研究成果: Article査読

34 被引用数 (Scopus)

抄録

Axinelloside A was isolated from the lipophilic extract of the Japanease marine sponge Axinella infundibula as a strong human telomerase inhibitor (IC50 2.0 μg/mL). It has the molecular weight of 4780.4 as the monoisotopic mass of the 19 sodium salt. The chemical structure was elucidated mainly by spectroscopic methods (2D NMR and MS). Axinelloside A consists of twelve sugars, e.g., a scyllo-inositol, a D-arabinose, 5 D-galactoses, and 5 L-fucoses, together with an (R)-3-hydroxy-octadecanoic acid, 3 (E)-2-hexadecenoic acids, and 19 sulfates.

本文言語English
ページ(範囲)13262-13270
ページ数9
ジャーナルJournal of the American Chemical Society
127
38
DOI
出版ステータスPublished - 2005 9 28
外部発表はい

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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