Basal gene expression of vascular endothelial growth factor-related transcriptional factors in rat skeletal muscle differs between slow and fast fiber types

Takeshi Otsuki*, Seiji Maeda, Motoyuki Iemitsu, Subrina Jesmin, Takashi Miyauchi

*この研究の対応する著者

研究成果: Article査読

抄録

Skeletal muscle is comprised of multiple fiber types. Slow-twitch oxidative muscle fibers have greater capillary density compared with fast-twitch glycolytic fibers of skeletal muscle. To gain insight into the molecular mechanism underlying the difference of capillary density, we investigated whether the basal gene expression of vascular endothelial growth factor (VEGF), a major angiogenesis-related factor, and its transcriptional factors (hypoxia-inducible factor-1α, transforming growth factor-β1, c-jun, and c-fos) differs between these two fiber types of rat skeletal muscle. The mRNA expression of VEGF and its transcriptional factors was significantly higher in slow type fiber of muscle (soleus muscle) compared with fast type fiber of muscle (plantaris and tibialis anterior muscles). These results suggest that the difference of basal gene expression of VEGF and its transcriptional factors between slow and fast fiber types of skeletal muscle may partly contribute to the difference in capillary density between these two fiber types.

本文言語English
ページ(範囲)65-69
ページ数5
ジャーナルjapanese journal of physical fitness and sports medicine
55
SUPPL.
DOI
出版ステータスPublished - 2006 10月
外部発表はい

ASJC Scopus subject areas

  • 整形外科およびスポーツ医学
  • 理学療法、スポーツ療法とリハビリテーション

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