Bayesian clinical classification from high-dimensional data: Signatures versus variability

Akram Shalabi, Masato Inoue, Johnathan Watkins, Emanuele De Rinaldis, Anthony C.C. Coolen*


研究成果: Article査読

5 被引用数 (Scopus)


When data exhibit imbalance between a large number d of covariates and a small number n of samples, clinical outcome prediction is impaired by overfitting and prohibitive computation demands. Here we study two simple Bayesian prediction protocols that can be applied to data of any dimension and any number of outcome classes. Calculating Bayesian integrals and optimal hyperparameters analytically leaves only a small number of numerical integrations, and CPU demands scale as O(nd). We compare their performance on synthetic and genomic data to the mclustDA method of Fraley and Raftery. For small d they perform as well as mclustDA or better. For d = 10,000 or more mclustDA breaks down computationally, while the Bayesian methods remain efficient. This allows us to explore phenomena typical of classification in high-dimensional spaces, such as overfitting and the reduced discriminative effectiveness of signatures compared to intra-class variability.

ジャーナルStatistical Methods in Medical Research
出版ステータスPublished - 2018 2月 1

ASJC Scopus subject areas

  • 疫学
  • 統計学および確率
  • 健康情報管理


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