Biodegradable and Electroactive TEMPO-Substituted Acrylamide/Lactide Copolymers

Xiuli Zhuang, Han Zhang, Natsuru Chikushi, Changwen Zhao, Kenichi Oyaizu, Xuesi Chen, Hiroyuki Nishide

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Copolymers composed of PLA and PTAm were prepared by a macromonomer approach. The PLA bearing vinyl group at chain end was copolymerized with 2,2,6,6-tetrametylpiperidine-4-ylacrylamide. The resulted copolymers were oxidized by a peroxide to give PTAm-g-PLA. The structures of the copolymers were confirmed by NMR and FTIR spectroscopy. The comparison of 1H NMR results and SQUID measurements demonstrated that the oxidation of the PTAm fragment proceeded almost to completion. An MTT assay, cell adhesion and spreading evaluation showed that the copolymers exhibited improved cytocompatibility as compared to the PTAm homopolymer due to the introduction of the biocompatible PLA moiety.Novel PTAm-g-PLA copolymers were successfully prepared by a PLA macromonomer approach. The obtained copolymer contained stable radical units which was biologically active. MTT assay and cell adhesion and spreading evaluation showed that the copolymers exhibited improved cytocompatibility as compared to the PTAm homopolymer due to the introduction of the biocompatible PLA moiety. The copolymers are expected to have promising applications in tissue engineering.

本文言語English
ページ(範囲)1203-1209
ページ数7
ジャーナルMacromolecular Bioscience
10
10
DOI
出版ステータスPublished - 2010 10 1

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

フィンガープリント 「Biodegradable and Electroactive TEMPO-Substituted Acrylamide/Lactide Copolymers」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル