Bioengineering of bacterial magnetic particles and their applications in biotechnology

Tomoko Yoshino, Yoshiaki Maeda, Tadashi Matsunaga*

*この研究の対応する著者

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Magnetic particles have attracted much attention for their versatile uses in biotechnology, especially in medical applications. The major advantage of magnetic particles is that they can be easily manipulated by magnetic forces. Mag-netotactic bacteria synthesize nano-sized biomagnetites, otherwise known as bacterial magnetic particles (BacMPs) that are individually enveloped by a lipid bilayer membrane. The mechanisms of BacMP synthesis have been analyzed by ge-nomic, proteomic, and bioinformatic approaches. Based on those studies in Magnetospirillum magneticum AMB-1, functional nanomaterials have been designed and produced. Through genetic engineering, functional proteins such as enzymes, antibodies, and receptors have been successfully displayed on BacMPs. These functional BacMPs have been utilized in various biosensors and bio-separation processes. Here, recent papers and patents for bioengineering of BacMPs and their applications in biotechnology are reviewed. The elucidation of the mechanism of magnetic particle synthesis has provided a roadmap for the design of novel biomaterials that can play useful roles in multiple disciplinary fields.

本文言語English
ページ(範囲)214-225
ページ数12
ジャーナルRecent Patents on Biotechnology
4
3
DOI
出版ステータスPublished - 2010
外部発表はい

ASJC Scopus subject areas

  • バイオテクノロジー
  • 応用微生物学とバイオテクノロジー
  • バイオエンジニアリング

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