抜粋
A pathway is proposed for the biosynthesis of the unique homodimeric terpene, halichonadin H. The proposed biosynthetic pathway involves two key Passerini reactions of eudesmane-type terpene isocyanides. The Passerini reaction of a model terpene isocyanide and formaldehyde afforded an α-hydroxy acetamide, which was further subjected to oxidation and a second Passerini reaction. This reaction sequence furnished an α-hydroxy malonamide connected with two identical terpene units which is the identical structural motif found in halichonadin H.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 2305-2310 |
| ページ数 | 6 |
| ジャーナル | Synthesis (Germany) |
| 巻 | 51 |
| 発行部数 | 11 |
| DOI | |
| 出版物ステータス | Published - 2019 1 1 |
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry
フィンガープリント Bioinspired Synthesis of the Central Core of Halichonadin H: The Passerini Reaction in a Hypothetical Biosynthesis of Marine Natural Products' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。
これを引用
Ichikawa, Y., Yamasaki, T., Nakanishi, K., Udagawa, Y., Hosokawa, S., & Masuda, T. (2019). Bioinspired Synthesis of the Central Core of Halichonadin H: The Passerini Reaction in a Hypothetical Biosynthesis of Marine Natural Products. Synthesis (Germany), 51(11), 2305-2310. https://doi.org/10.1055/s-0037-1610867