Biomechanical Modeling to Improve Coronary Artery Bifurcation Stenting: Expert Review Document on Techniques and Clinical Implementation

Antonios P. Antoniadis, Peter Mortier, Ghassan Kassab, Gabriele Dubini, Nicolas Foin, Yoshinobu Murasato, Andreas A. Giannopoulos, Shengxian Tu, Kiyotaka Iwasaki, Yutaka Hikichi, Francesco Migliavacca, Claudio Chiastra, Jolanda J. Wentzel, Frank Gijsen, Johan H.C. Reiber, Peter Barlis, Patrick W. Serruys, Deepak L. Bhatt, Goran Stankovic, Elazer R. EdelmanGeorge D. Giannoglou, Yves Louvard, Yiannis S. Chatzizisis*

*この研究の対応する著者

研究成果: Review article査読

63 被引用数 (Scopus)

抄録

Treatment of coronary bifurcation lesions remains an ongoing challenge for interventional cardiologists. Stenting of coronary bifurcations carries higher risk for in-stent restenosis, stent thrombosis, and recurrent clinical events. This review summarizes the current evidence regarding application and use of biomechanical modeling in the study of stent properties, local flow dynamics, and outcomes after percutaneous coronary interventions in bifurcation lesions. Biomechanical modeling of bifurcation stenting involves computational simulations and in vitro bench testing using subject-specific arterial geometries obtained from in vivo imaging. Biomechanical modeling has the potential to optimize stenting strategies and stent design, thereby reducing adverse outcomes. Large-scale clinical studies are needed to establish the translation of pre-clinical findings to the clinical arena.

本文言語English
論文番号2103
ページ(範囲)1281-1296
ページ数16
ジャーナルJACC: Cardiovascular Interventions
8
10
DOI
出版ステータスPublished - 2015 8 24

ASJC Scopus subject areas

  • 循環器および心血管医学

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