Biomedical Engineering Analysis of the Rupture Risk of Cerebral Aneurysms: Flow Comparison of Three Small Pre-ruptured Versus Six Large Unruptured Cases

A. Kamoda, T. Yagi, A. Sato, Y. Qian, K. Iwasaki, M. Umezu, T. Akutsu, H. Takao, Y. Murayama

研究成果: Conference contribution

2 被引用数 (Scopus)

抄録

A relationship between blood flows in cerebral aneurysms and their rupture remains obscure. In clinical practice, the size of aneurysms is one of the important factors for determining a strategy of treatment, but in our database three small aneurysms became ruptured during follow-up. Here, we aim to study their pre-ruptured hemodynamics, and differentiate them with those of six large unruptured aneurysms. All the aneurysms occurred in internal carotid artery, and their mean sizes were 6 and 10.8 mm for pre-ruptured and unruptured cases, respectively. We reproduced their replica as a patient-specific elastic model using clinical images obtained by digital subtraction angiography and a series of rapid prototyping techniques. Flows were reproduced in vitro using a cerebral flow simulator, and visualized by Time-resolved Particle Image Velocimetry. All pre-ruptured cases showed the collision of an incoming flow at a distal neck, and formed a prominent jet stream directing towards the aneurismal head. In contrast, none of unruptured aneurysms had such a marked impingement, and their flows were most likely characterized by swirling patterns. All unruptured cases occurred in a twisted vessel, or carotid siphon, whereas pre-ruptured ones were located downstream whose geometries consisted of a simple curvature. These findings suggest that internal carotid artery has a regional dependency of the risk of aneurismal rupture. Furthermore, the presence of jet streams for smallsized aneurysms may be a substantial indicator of the rupture and immediate treatments.

本文言語English
ホスト出版物のタイトル13th International Conference on Biomedical Engineering - ICBME 2008
ページ1600-1603
ページ数4
DOI
出版ステータスPublished - 2009 12 1
イベント13th International Conference on Biomedical Engineering, ICBME 2008 - , Singapore
継続期間: 2008 12 32008 12 6

出版物シリーズ

名前IFMBE Proceedings
23
ISSN(印刷版)1680-0737

Conference

Conference13th International Conference on Biomedical Engineering, ICBME 2008
国/地域Singapore
Period08/12/308/12/6

ASJC Scopus subject areas

  • バイオエンジニアリング
  • 生体医工学

フィンガープリント

「Biomedical Engineering Analysis of the Rupture Risk of Cerebral Aneurysms: Flow Comparison of Three Small Pre-ruptured Versus Six Large Unruptured Cases」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル