Biomolecular sensors utilizing waveguide modes excited by evanescent fields

M. Fujimaki*, C. Rockstuhl, X. Wang, K. Awazu, J. Tominaga, T. Ikeda, Y. Koganezawa, Y. Ohki

*この研究の対応する著者

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Properties of evanescent-field-coupled waveguide-mode sensors consisting of a multi-layer structure made of a SiO2 waveguide, a thin metal layer (Au, Cu, W or Ti), and a high refractive index glass substrate illuminated under the Kretschmann configuration have been theoretically and experimentally investigated. In all cases, reflectivity changes attributed to streptavidin combining to biotinyl groups were observed in close spectral vicinity of the waveguide resonances. The sensors with the Au and the Cu layers show superior sensitivity as compared to those with the W and the Ti layers, whereas the W and Ti layers show better thermal and chemical stability. The results indicate that the materials of thin metal layers should be chosen in accordance with the purpose of sensors and/or environment in which the sensors are used.

本文言語English
ページ(範囲)320-326
ページ数7
ジャーナルJournal of Microscopy
229
2
DOI
出版ステータスPublished - 2008 2

ASJC Scopus subject areas

  • 病理学および法医学
  • 組織学

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