Biosensing by optical waveguide spectroscopy based on localized surface plasmon resonance of gold nanoparticles used as a probe or as a label

Mayuki Kajiura, Takuya Nakanishi, Hironori Iida, Harumi Takada, Tetsuya Osaka*

*この研究の対応する著者

研究成果: Article査読

26 被引用数 (Scopus)

抄録

The application of localized surface plasmon resonance (LSPR) of gold nanoparticles for the detection of biotin-streptavidin binding, as a typical biological reaction, was investigated by using optical waveguide spectroscopy, and two different modes for the use of gold nanoparticles, one as a probe and the other as a label were compared with each other. The combination with optical waveguide spectroscopy was found to bring about a high sensitivity for the biomolecular detection system using LSPR of gold nanoparticles in both modes. In particular, the mode using gold nanoparticles as a label was demonstrated to be of advantage to devising proper procedures for using nanoparticles and evaluating actual response relevant to the phenomenon concerned, and thus to sensitive detection.

本文言語English
ページ(範囲)140-145
ページ数6
ジャーナルJournal of Colloid And Interface Science
335
1
DOI
出版ステータスPublished - 2009 7月 1

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 生体材料
  • 表面、皮膜および薄膜
  • コロイド化学および表面化学

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