Bisoxazolomycin A: A new natural product from 'Streptomyces subflavus subsp. irumaensis' AM-3603

Wilaiwan Koomsiri, Yuki Inahashi, Toru Kimura, Kazuro Shiomi, Yoko Takahashi, Satoshi Omura, Arinthip Thamchaipenet, Takuji Nakashima

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Bisoxazolomycin (1), oxazolomycin A2 (2) and oxazolomycin A (3) were identified by physicochemical screening approach from a culture broth of 'Streptomyces subflavus subsp. irumaensis' AM-3603. Compound 2 is a hydrolyzed analog of 3 at the β-lactone ring, and 1 is a new dimeric analog of 2. Compounds 1 and 2 exhibited less potent antibacterial activity and cytotoxicity than 3, which might be due to lack of the β-lactone ring.

本文言語English
ページ(範囲)1142-1145
ページ数4
ジャーナルJournal of Antibiotics
70
12
DOI
出版ステータスPublished - 2017 12 1
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 創薬

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