Although protein adsorption is the first event when blood comes in contact with foreign surfaces, adsorbed proteins would be expected to be reoriented or denatured in a time-lapse process. In addition, the protein layer formed must be reorganized via dynamic exchange with circulating plasma proteins during long-term implantation. It is not exactly known how antithrombogenicity is acquired and what mechanism dominates especially for long-term implantation. In the study reported here; detailed analyses of segmented polyurethane surfaces implanted for weeks to months are presented with the aid of modern microscopic and spectroscopic instruments. Based on experimental observations, 'multilayered proteinaceous passivation', which is quite contrary to the early albumin monolayer passivation hypothesis, is a newly proposed and conceptualized theory for long-term antithrombogenicity.
|ジャーナル||Transactions - American Society for Artificial Internal Organs|
|出版ステータス||Published - 1984 12 1|
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