抄録
Background & aims: Recently, we described a novel surface-modified lipid vesicle formulation (liposome) that had very high targeting to bone marrow in normal rabbits. Because the bone marrow is the site of hematopoiesis, bone marrow-targeted drug-delivery systems have many potential applications. In this study we investigated whether these bone marrow-targeted vesicles are also similarly effective for bone marrow targeting in rhesus monkeys, a primate animal model that is more relevant to humans. Materials & methods: The preformed vesicles encapsulating 30mM glutathione were labeled with technetium-99m (99mTc) for scintigraphic imaging. The vesicles were 216 ± 21 nm in diameter with a negative surface charge composed of DPPC, cholesterol, anionic amphiphile and poly(ethylene glycol)-DSPE (1:1:0.2:0.013 molar ratio). Results: The whole-body images of rhesus monkeys receiving intravenous 99mTc vesicles revealed high uptake of the 99mTc vesicles in bone marrow. Based on image analysis, we estimated that approximately 70% of the injected dose of the 99mTc vesicles was taken up by the bone marrow. Conclusion: This finding increases the feasibility of using this bone marrow-specific drug-delivery system for clinical applications.
本文言語 | English |
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ページ(範囲) | 41-49 |
ページ数 | 9 |
ジャーナル | Nanomedicine |
巻 | 5 |
号 | 1 |
DOI | |
出版ステータス | Published - 2010 1月 |
ASJC Scopus subject areas
- 材料科学(全般)
- バイオエンジニアリング
- 生体医工学
- 医学(その他)
- 開発