Bone marrow-targeted liposomal carriers: A feasibility study in nonhuman primates

Keitaro Sou, Beth Goins, Michelle M. Leland, Eishun Tsuchida, William T. Phillips

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Background & aims: Recently, we described a novel surface-modified lipid vesicle formulation (liposome) that had very high targeting to bone marrow in normal rabbits. Because the bone marrow is the site of hematopoiesis, bone marrow-targeted drug-delivery systems have many potential applications. In this study we investigated whether these bone marrow-targeted vesicles are also similarly effective for bone marrow targeting in rhesus monkeys, a primate animal model that is more relevant to humans. Materials & methods: The preformed vesicles encapsulating 30mM glutathione were labeled with technetium-99m (99mTc) for scintigraphic imaging. The vesicles were 216 ± 21 nm in diameter with a negative surface charge composed of DPPC, cholesterol, anionic amphiphile and poly(ethylene glycol)-DSPE (1:1:0.2:0.013 molar ratio). Results: The whole-body images of rhesus monkeys receiving intravenous 99mTc vesicles revealed high uptake of the 99mTc vesicles in bone marrow. Based on image analysis, we estimated that approximately 70% of the injected dose of the 99mTc vesicles was taken up by the bone marrow. Conclusion: This finding increases the feasibility of using this bone marrow-specific drug-delivery system for clinical applications.

本文言語English
ページ(範囲)41-49
ページ数9
ジャーナルNanomedicine
5
1
DOI
出版ステータスPublished - 2010 1

ASJC Scopus subject areas

  • 材料科学(全般)
  • バイオエンジニアリング
  • 生体医工学
  • 医学(その他)
  • 開発

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