Brain and pineal 7α-hydroxypregnenolone stimulating locomotor activity: Identification, mode of action and regulation of biosynthesis

Kazuyoshi Tsutsui*, Shogo Haraguchi, Yoshitaka Fukada, Hubert Vaudry

*この研究の対応する著者

    研究成果: Article査読

    18 被引用数 (Scopus)

    抄録

    Biologically active steroids synthesized in the central and peripheral nervous systems are termed neurosteroids. However, the biosynthetic pathways leading to the formation of neurosteroids are still incompletely elucidated. 7α-Hydroxypregnenolone, a novel bioactive neurosteroid stimulating locomotor activity, has been recently identified in the brain of newts and quail. Subsequently, the mode of action and regulation of biosynthesis of 7α-hydroxypregnenolone have been determined. Moreover, recent studies on birds have demonstrated that the pineal gland, an endocrine organ located close to the brain, is an important site of production of neurosteroids de novo from cholesterol. 7α-Hydroxypregnenolone is a major pineal neurosteroid that stimulates locomotor activity in juvenile chickens, connecting light-induced gene expression with locomotion. This review summarizes the advances in our understanding of the identification, mode of action and regulation of biosynthesis of brain and pineal 7α-hydroxypregnenolone, a potent stimulator of locomotor activity.

    本文言語English
    ページ(範囲)179-189
    ページ数11
    ジャーナルFrontiers in Neuroendocrinology
    34
    3
    DOI
    出版ステータスPublished - 2013 8

    ASJC Scopus subject areas

    • 内分泌系および自律システム

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