Brain-derived neurotrophic factor treatment increases the skeletal muscle glucose transporter 4 protein expression in mice

M. Suwa, K. I. Yamamoto, H. Nakano, H. Sasaki, Zsolt Radak, S. Kumagai

研究成果: Article

15 引用 (Scopus)

抄録

The purpose of the present study was to investigate whether peripheral brain-derived neurotrophic factor (BDNF) treatment induced metabolic adaptations in mouse skeletal muscle. BDNF (20 mg/kg/day) was injected subcutaneously for successive 14 days. BDNF treatment significantly reduced the total food intake and inhibited the weight gain in comparison to the control group. The glucose transporter 4 (GLUT4) protein expression in the gastrocnemius muscle was significantly increased by BDNF treatment in comparison to the control and pair-fed groups. Neither the oxidative nor the glycolytic enzyme activities in the gastrocnemius muscle changed after the BDNF treatment. These results suggest that the peripheral BDNF treatment promotes the skeletal muscle GLUT4 protein expression as well as hypophagia.

元の言語English
ページ(範囲)619-623
ページ数5
ジャーナルPhysiological Research
59
発行部数4
出版物ステータスPublished - 2010 11 1
外部発表Yes

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Facilitative Glucose Transport Proteins
Brain-Derived Neurotrophic Factor
Skeletal Muscle
Proteins
Weight Gain
Eating
Control Groups
Enzymes

ASJC Scopus subject areas

  • Physiology

これを引用

Brain-derived neurotrophic factor treatment increases the skeletal muscle glucose transporter 4 protein expression in mice. / Suwa, M.; Yamamoto, K. I.; Nakano, H.; Sasaki, H.; Radak, Zsolt; Kumagai, S.

:: Physiological Research, 巻 59, 番号 4, 01.11.2010, p. 619-623.

研究成果: Article

Suwa, M. ; Yamamoto, K. I. ; Nakano, H. ; Sasaki, H. ; Radak, Zsolt ; Kumagai, S. / Brain-derived neurotrophic factor treatment increases the skeletal muscle glucose transporter 4 protein expression in mice. :: Physiological Research. 2010 ; 巻 59, 番号 4. pp. 619-623.
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