Brain-derived neurotrophic factor treatment increases the skeletal muscle glucose transporter 4 protein expression in mice

M. Suwa, K. I. Yamamoto, H. Nakano, H. Sasaki, Z. Radak, S. Kumagai

研究成果: Article査読

16 被引用数 (Scopus)

抄録

The purpose of the present study was to investigate whether peripheral brain-derived neurotrophic factor (BDNF) treatment induced metabolic adaptations in mouse skeletal muscle. BDNF (20 mg/kg/day) was injected subcutaneously for successive 14 days. BDNF treatment significantly reduced the total food intake and inhibited the weight gain in comparison to the control group. The glucose transporter 4 (GLUT4) protein expression in the gastrocnemius muscle was significantly increased by BDNF treatment in comparison to the control and pair-fed groups. Neither the oxidative nor the glycolytic enzyme activities in the gastrocnemius muscle changed after the BDNF treatment. These results suggest that the peripheral BDNF treatment promotes the skeletal muscle GLUT4 protein expression as well as hypophagia.

本文言語English
ページ(範囲)619-623
ページ数5
ジャーナルPhysiological Research
59
4
出版ステータスPublished - 2010
外部発表はい

ASJC Scopus subject areas

  • 生理学

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