Breaking Up Prolonged Sitting with Standing or Walking Attenuates the Postprandial Metabolic Response in Postmenopausal Women: A Randomized Acute Study

Joseph Henson*, Melanie J. Davies, Danielle H. Bodicoat, Charlotte L. Edwardson, Jason M.R. Gill, David J. Stensel, Keith Tolfrey, David W. Dunstan, Kamlesh Khunti, Thomas Yates

*この研究の対応する著者

研究成果: Article査読

171 被引用数 (Scopus)

抄録

OBJECTIVE To determine whether breaking up prolonged sitting with short bouts of standing or walking improves postprandialmarkers of cardiometabolic health in women at high risk of type 2 diabetes. RESEARCH DESIGN AND METHODS Twenty-two overweight/obese, dysglycemic, postmenopausal women (mean 6 SD age 66.6 6 4.7 years) each participated in two of the following treatments: prolonged, unbroken sitting (7.5 h) or prolonged sitting broken up with either standing or walking at a self-perceived light intensity (for 5 min every 30 min). Both allocation and treatment order were randomized. The incremental area under the curves (iAUCs) for glucose, insulin, nonesterified fatty acids (NEFA), and triglycerides were calculated for each treatment condition (mean 6 SEM). The following day, all participants underwent the 7.5-h sitting protocol. RESULTS Compared with a prolonged bout of sitting (iAUC 5.3 ± 0.8 mmol/L • h), both standing (3.5 ± 0.8 mmol/L • h) and walking (3.8 ± 0.7 mmol/L • h) significantly reduced the glucose iAUC (both P < 0.05). When comparedwith prolonged sitting (548.2 ± 71.8 mU/L • h), insulin was also reduced for both activity conditions (standing, 437.2 ± 73.5 mU/L • h; walking, 347.9 ± 78.7 mU/L • h; both P < 0.05). Both standing (21.0 ± 0.2 mmol/L • h) and walking (20.8 ± 0.2 mmol/L • h) attenuated the suppression of NEFA compared with prolonged sitting (21.5 ± 0.2 mmol/L • h) (both P < 0.05). There was no significant effect on triglyceride iAUC. The effects on glucose (standing andwalking) and insulin (walking only) persisted into the following day. CONCLUSIONS Breaking up prolonged sitting with 5-min bouts of standing or walking at a selfperceived light intensity reduced postprandial glucose, insulin, and NEFA responses in women at high risk of type 2 diabetes. This simple, behavioral approach could informfuture public health interventions aimed at improving themetabolic profile of postmenopausal, dysglycemic women.

本文言語English
ページ(範囲)130-138
ページ数9
ジャーナルDiabetes care
39
1
DOI
出版ステータスPublished - 2016 1月
外部発表はい

ASJC Scopus subject areas

  • 内科学
  • 内分泌学、糖尿病および代謝内科学
  • 高度および特殊看護

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