TY - JOUR
T1 - C-H bond functionalization
T2 - Emerging synthetic tools for natural products and pharmaceuticals
AU - Yamaguchi, Junichiro
AU - Yamaguchi, Atsushi D.
AU - Itami, Kenichiro
PY - 2012/9/3
Y1 - 2012/9/3
N2 - The direct functionalization of C-H bonds in organic compounds has recently emerged as a powerful and ideal method for the formation of carbon-carbon and carbon-heteroatom bonds. This Review provides an overview of C-H bond functionalization strategies for the rapid synthesis of biologically active compounds such as natural products and pharmaceutical targets. The ideal case: The direct functionalization of C-H bonds in organic compounds has recently emerged as a powerful and ideal method for the formation of carbon-carbon and carbon-heteroatom bonds. This Review provides an overview of C-H functionalization strategies for the rapid synthesis of biologically active compounds such as natural products and pharmaceutical targets.
AB - The direct functionalization of C-H bonds in organic compounds has recently emerged as a powerful and ideal method for the formation of carbon-carbon and carbon-heteroatom bonds. This Review provides an overview of C-H bond functionalization strategies for the rapid synthesis of biologically active compounds such as natural products and pharmaceutical targets. The ideal case: The direct functionalization of C-H bonds in organic compounds has recently emerged as a powerful and ideal method for the formation of carbon-carbon and carbon-heteroatom bonds. This Review provides an overview of C-H functionalization strategies for the rapid synthesis of biologically active compounds such as natural products and pharmaceutical targets.
KW - C-H functionalization
KW - natural products
KW - pharmaceuticals
KW - synthetic methods
UR - http://www.scopus.com/inward/record.url?scp=84865838463&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865838463&partnerID=8YFLogxK
U2 - 10.1002/anie.201201666
DO - 10.1002/anie.201201666
M3 - Review article
C2 - 22887739
AN - SCOPUS:84865838463
VL - 51
SP - 8960
EP - 9009
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 36
ER -