Calicheamicin θ 1I: A Rationally Designed Molecule with Extremely Potent and Selective DNA Cleaving Properties and Apoptosis Inducing Activity

K. C. Nicolaou, T. Li, Masahisa Nakada, Conrad W. Hummel, A. Hiatt, W. Wrasidlo

研究成果: Article

54 被引用数 (Scopus)

抄録

The attack of a thiolate ion on the trisulfide unit of natural calicheamicin γ I1 (1) activates it to form a diradical, which then attacks DNA. Thioacetate 2 is even more readily activated—under mildly basic conditions caused by OH ions—and likewise exhibits extremely interesting biological properties. (Figure Presented.)

本文言語English
ページ(範囲)183-186
ページ数4
ジャーナルAngewandte Chemie International Edition in English
33
2
DOI
出版ステータスPublished - 1994 2 1
外部発表はい

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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