Carbon monoxide as an endogenous modulator of hepatic vascular perfusion

Makoto Suematsu, Satoshi Kashiwagi, Tsuyoshi Sano, Nobuhito Goda, Yuichi Shinoda, Yuzuru Ishimura

研究成果: Article査読

137 被引用数 (Scopus)

抄録

Carbon monoxide (CO) generated by heme oxygenase has recently been considered a neural messenger in brain. This observation prompted us to investigate whether CO participates in vascular regulation in the liver, another organ with high levels of heme oxygenase activity. In isolated perfused rat liver, submicromolar levels of CO were detectable in the effluent and were able to be suppressed by the administration of Zn protoporphyrin IX (1 μM), a potent inhibitor of heme oxygenase. Furthermore, zinc protoporphyrin IX (1 μM) promoted an increase in the perfusion pressure under the constant flow conditions. These changes were reversed by adding CO (2 μM) or a cGMP analogue 8-bromo-cGMP (1 μM) in the perfusate. The present findings indicate that CO can function as an endogenous modulator of vascular perfusion in the liver.

本文言語English
ページ(範囲)1333-1337
ページ数5
ジャーナルBiochemical and Biophysical Research Communications
205
2
DOI
出版ステータスPublished - 1994 12 15
外部発表はい

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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