Cardiac oxidative stress and the therapeutic approaches to the intake of antioxidant supplements and physical activity

Kosar Valaei, Shima Taherkhani, Hamid Arazi*, Katsuhiko Suzuki

*この研究の対応する著者

研究成果: Review article査読

1 被引用数 (Scopus)

抄録

Reactive oxygen species (ROS) are strongly reactive chemical entities that include oxygen regulated by enzymatic and non-enzymatic antioxidant defense mechanisms. ROS contribute significantly to cell homeostasis in the heart by regulating cell proliferation, differentiation, and excitation-contraction coupling. When ROS generation surpasses the ability of the antioxidant defense mechanisms to buffer them, oxidative stress develops, resulting in cellular and molecular disorders and eventually in heart failure. Oxidative stress is a critical factor in developing hypoxia-and ischemia-reperfusion-related cardiovascular disorders. This article aimed to discuss the role of oxidative stress in the pathophysiology of cardiac diseases such as hypertension and endothelial dysfunction. This review focuses on the various clinical events and oxidative stress associated with cardiovascular pathophysiology, highlighting the benefits of new experimental treatments such as creatine supplementation, omega-3 fatty acids, microRNAs, and antioxidant supplements in addition to physical exercise.

本文言語English
論文番号3483
ジャーナルNutrients
13
10
DOI
出版ステータスPublished - 2021 10

ASJC Scopus subject areas

  • 食品科学
  • 栄養および糖尿病

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