Ca2+ release from Ca2+ stores, particularly from ryanodine-sensitive Ca2+ stores, is required for the induction of LTD in cultured cerebellar Purkinje cells

K. Kohda, T. Inoue*, K. Mikoshiba

*この研究の対応する著者

研究成果: Article査読

61 被引用数 (Scopus)

抄録

1. Primary-cultured cerebellar Purkinje cells (PCs) from mouse embryos were whole cell voltage clamped, and L-glutamate (Glu) was applied iontophoretically to the dendrite. Long-term depression (LTD) of Glu-evoked currents was induced through the conjunction of repeated depolarizations and Glu applications. 2. Thapsigargin, a specific inhibitor of Ca2+-ATPase on the endoplasmic reticulum, and ryanodine and ruthenium red, inhibitors of the ryanodine receptor, blocked the induction of LTD. 3. Thapsigargin and ryanodine alone did not affect influx of Ca2+ through voltage-gated Ca2+ channels and inward currents evoked by Glu applications. 4. Our results suggest that Ca2+ release from internal stores, particularly from ryanodine-sensitive stores, is necessary for the induction of LTD in cultured PCs.

本文言語English
ページ(範囲)2184-2188
ページ数5
ジャーナルJournal of Neurophysiology
74
5
DOI
出版ステータスPublished - 1995 1 1
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)
  • 生理学

フィンガープリント

「Ca<sup>2+</sup> release from Ca<sup>2+</sup> stores, particularly from ryanodine-sensitive Ca<sup>2+</sup> stores, is required for the induction of LTD in cultured cerebellar Purkinje cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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