Ca2+ signaling regulated by an ATP-dependent autocrine mechanism in astrocytes

H. Shiga, T. Tojima, E. Ito*

*この研究の対応する著者

研究成果: Article査読

27 被引用数 (Scopus)

抄録

Although the mechanisms of Ca2+ wave propagation in astrocytes induced by mechanical stimulation have been well studied, it is still not known how the [Ca2+]i increases in the stimulated cells. Here, we have analyzed the mechanisms of [Ca2+]i increase in single, isolated astrocytes. Our results showed that there was an autocrine mechanism of Ca2+ regulation mediated by ATP in mechanically stimulated astrocytes. This autocrine mechanism induced the activation of phospholipase C via a G-protein, resulting in Ca2+ release from intracellular Ca2+ stores. A second pathway mediating a [Ca2+]i increase was via a Ca2+ influx from the extracellular space, which, interestingly, suppressed an intracellular Ca2+ oscillation. These two different Ca2+ cascades are involved in signal transduction and may function separately during intercellular communication.

本文言語English
ページ(範囲)2619-2622
ページ数4
ジャーナルNeuroReport
12
12
DOI
出版ステータスPublished - 2001 8 28
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

フィンガープリント

「Ca<sup>2+</sup> signaling regulated by an ATP-dependent autocrine mechanism in astrocytes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル