@article{588c3b9101e24a7c9d41fc6281662292,
title = "Catalytic Asymmetric Intramolecular Cyclopropanation of α-Diazo-α-Silyl Acetate",
abstract = "The catalytic asymmetric intramolecular cyclopropanation (CAIMCP) of α-diazo-α-silyl acetates to form oxabicyclo[3.2.1]hexane, which proceeds with high yields and enantioselectivities, is described. The maximum enantiomeric excess observed was 96% ee and the absolute configuration of the products was elucidated. The counteranion of the Cu(I) catalyst was found to play a crucial role in determining the yields and enantioselectivities, with highly anionic counteranions improving both yields and enantioselectivities. Our previously reported model explains the enantiofacial selectivity of the reacting alkene.",
keywords = "asymmetric catalysis, cyclopropanation, diazo compounds, enantioselectivity, lactones",
author = "Saori Inoue and Kotaro Nagatani and Haruka Tezuka and Yunosuke Hoshino and Masahisa Nakada",
note = "Funding Information: We acknowledge support from the Materials Characterization Central Laboratory, Waseda University, for characterization of new compounds. This work was financially supported in part by a Grant-in-Aid for Scientific Research on Innovative Areas 2707 Middle molecular strategy from MEXT, and by a Waseda University Grant for Special Research Projects. Publisher Copyright: {\textcopyright} Georg Thieme Verlag Stuttgart.New York.",
year = "2017",
month = jun,
day = "1",
doi = "10.1055/s-0036-1588414",
language = "English",
volume = "28",
pages = "1065--1070",
journal = "Synlett",
issn = "0936-5214",
publisher = "Georg Thieme Verlag",
number = "9",
}