Catalytic Enantioselective Synthesis of a Pyrrolizidine-Alkaloid-Inspired Compound Collection with Antiplasmodial Activity

Zhi Jun Jia, Hiroshi Takayama, Yushi Futamura, Harumi Aono, Jonathan O. Bauer, Carsten Strohmann, Andrey P. Antonchick*, Hiroyuki Osada, Herbert Waldmann

*この研究の対応する著者

研究成果: Article査読

8 被引用数 (Scopus)

抄録

A novel enantioselective approach to the synthesis of a compound collection inspired by natural pyrrolizidine alkaloids was developed, employing an enantioselectively catalyzed 1,3-dipolar cycloaddition as the key step. The cycloadducts were obtained with excellent enantio- and diastereoselectivity. Biological evaluation of the resulting compound collection revealed that the compound class has multiple bioactivities, including activity against Plasmodium falciparum 3D7 and inhibition of Hedgehog signaling.

本文言語English
ページ(範囲)7033-7041
ページ数9
ジャーナルJournal of Organic Chemistry
83
13
DOI
出版ステータスPublished - 2018 7月 6
外部発表はい

ASJC Scopus subject areas

  • 有機化学

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