Catalytic three-component C-C bond forming dearomatization of bromoarenes with malonates and diazo compounds

Hiroki Kato, Itsuki Musha, Masaaki Komatsuda, Kei Muto, Junichiro Yamaguchi

研究成果: Article査読

1 被引用数 (Scopus)

抄録

A Pd-catalyzed dearomative three-component C-C bond formation of bromoarenes with diazo compounds and malonates was developed. Various bromoarenes ranging from benzenoids to azines and heteroles were transformed to the corresponding substituted alicyclic molecules. The key to this reaction is the generation of a benzyl-palladium intermediate, which reacts with malonates to form a Pd-O-enolate species. Strikingly, the present method enabled rapid access to multi-substituted alicycles through subsequent elaboration of dearomatized products. This journal is

本文言語English
ページ(範囲)8779-8784
ページ数6
ジャーナルChemical Science
11
33
DOI
出版ステータスPublished - 2020 9 7

ASJC Scopus subject areas

  • Chemistry(all)

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