Catenulisporolides, Glycosylated Triene Macrolides from the Chemically Underexploited Actinomycete Catenulispora Species

Sangkeun Son, Young Soo Hong, Yushi Futamura, Mina Jang, Jae Kyoung Lee, Kyung Taek Heo, Sung Kyun Ko, Jung Sook Lee, Shunji Takahashi, Hiroyuki Osada, Jae Hyuk Jang*, Jong Seog Ahn

*この研究の対応する著者

研究成果: Article査読

9 被引用数 (Scopus)

抄録

New glycosylated 26-membered triene macrolides catenulisporolides, the first polyketide metabolites from Catenulispora species, were obtained by targeting slow-forming colonies on selection agar plates and applying long-term cultivation. Their structures, including the full stereochemistry, were defined by comprehensive spectroscopic and chemical methods and confirmed by bioinformatics analysis. Analysis of the genome sequence revealed the responsible biosynthetic gene cluster spanning ∼160 kbp, and feeding experiments with isotope-labeled precursors showed that isovaleric acid acts as a rare starter unit. Catenulisporolides exhibited antimalarial activities against resistant strains of Plasmodium falciparum, and enhanced activity was observed in semisynthetic derivatives.

本文言語English
ページ(範囲)7234-7238
ページ数5
ジャーナルOrganic Letters
20
22
DOI
出版ステータスPublished - 2018 11月 16
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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