Cation-π interaction in the polyolefin cyclization cascade uncovered by incorporating unnatural amino acids into the catalytic sites of squalene cyclase

Medicine & Life Sciences

• squalene cyclase 100%
• squalene-hopene cyclase 99%
• PL 732 77%
• Cyclization 69%
• Cations 47%
• Catalytic Domain 42%
• Amino Acids 32%
• Phenylalanine 25%
• Triterpenes 19%
• Temperature 16%
• oxidosqualene 16%
• O-methyltyrosine 16%
• Alicyclobacillus 14%
• Electrons 12%
• Squalene 11%
• Aromatic Amino Acids 11%
• Fluorine 10%
• Tryptophan 8%
• Tyrosine 7%
• Kinetics 5%

Engineering & Materials Science

• Cyclization 81%
• Polyolefins 61%
• Positive ions 57%
• Amino acids 55%
• Binding energy 44%
• Biosynthesis 14%
• Carboxylic acids 14%
• Carrier concentration 13%
• Fluorine 12%
• Temperature 11%
• Atoms 9%
• Electrons 9%
• Thermodynamic properties 8%
• Proteins 8%

Chemical Compounds

• Squalene 60%
• Polyolefin 51%
• Phenylalanine 46%
• Binding Energy 40%
• Triterpene 35%
• Cyclization Reaction 34%
• Aromatic Amino Acid 18%
• Acid 16%
• Tryptophan 14%
• Tyrosine 14%
• Kinetics Type 14%
• Fluorine Atom 13%
• Aromatic Structure 13%
• Biosynthesis 13%
• Protein 6%